Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients
Identifieur interne : 001F38 ( Main/Corpus ); précédent : 001F37; suivant : 001F39Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients
Auteurs : L. Pique ; S. Jegou ; X. Bertagna ; F. Javoy-Agid ; D. Seurin ; M. F. Proeschel ; F. Girard ; Y. Agid ; H. Vaudry ; J. P. LutonSource :
- Neuroscience Letters [ 0304-3940 ] ; 1984.
English descriptors
Abstract
The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.
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DOI: 10.1016/S0304-3940(85)80069-0
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ISTEX:E38C574F3DB3EAC392E36B0802A6E0FA2DA25472Le document en format XML
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Bertagna</name><affiliation><mods:affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Seurin, D" sort="Seurin, D" uniqKey="Seurin D" first="D." last="Seurin">D. Seurin</name><affiliation><mods:affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Proeschel, M F" sort="Proeschel, M F" uniqKey="Proeschel M" first="M. F." last="Proeschel">M. F. Proeschel</name><affiliation><mods:affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Girard, F" sort="Girard, F" uniqKey="Girard F" first="F." last="Girard">F. Girard</name><affiliation><mods:affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Vaudry, H" sort="Vaudry, H" uniqKey="Vaudry H" first="H." last="Vaudry">H. 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Pique</name><affiliation><mods:affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Jegou, S" sort="Jegou, S" uniqKey="Jegou S" first="S." last="Jegou">S. Jegou</name><affiliation><mods:affiliation>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</mods:affiliation></affiliation></author><author><name sortKey="Bertagna, X" sort="Bertagna, X" uniqKey="Bertagna X" first="X." last="Bertagna">X. Bertagna</name><affiliation><mods:affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Seurin, D" sort="Seurin, D" uniqKey="Seurin D" first="D." last="Seurin">D. Seurin</name><affiliation><mods:affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Proeschel, M F" sort="Proeschel, M F" uniqKey="Proeschel M" first="M. F." last="Proeschel">M. F. Proeschel</name><affiliation><mods:affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</mods:affiliation></affiliation></author><author><name sortKey="Girard, F" sort="Girard, F" uniqKey="Girard F" first="F." last="Girard">F. 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Luton</name><affiliation><mods:affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience Letters</title><title level="j" type="abbrev">NSL</title><idno type="ISSN">0304-3940</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="146">146</biblScope></imprint><idno type="ISSN">0304-3940</idno></series><idno type="istex">E38C574F3DB3EAC392E36B0802A6E0FA2DA25472</idno><idno type="DOI">10.1016/S0304-3940(85)80069-0</idno><idno type="PII">S0304-3940(85)80069-0</idno><idno type="ArticleID">80069</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson</term><term>gel filtration</term><term>hypothalamus</term><term>pro-opiomelanocortin</term><term>radioimmunoassay</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>L. Pique</name><affiliations><json:string>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</json:string></affiliations></json:item><json:item><name>S. Jegou</name><affiliations><json:string>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</json:string></affiliations></json:item><json:item><name>X. Bertagna</name><affiliations><json:string>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</json:string></affiliations></json:item><json:item><name>F. Javoy-Agid</name><affiliations><json:string>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</json:string></affiliations></json:item><json:item><name>D. Seurin</name><affiliations><json:string>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</json:string></affiliations></json:item><json:item><name>M.F. Proeschel</name><affiliations><json:string>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</json:string></affiliations></json:item><json:item><name>F. Girard</name><affiliations><json:string>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</json:string></affiliations></json:item><json:item><name>Y. Agid</name><affiliations><json:string>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</json:string></affiliations></json:item><json:item><name>H. Vaudry</name><affiliations><json:string>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</json:string></affiliations></json:item><json:item><name>J.P. Luton</name><affiliations><json:string>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>hypothalamus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pro-opiomelanocortin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>radioimmunoassay</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gel filtration</value></json:item></subject><articleId><json:string>80069</json:string></articleId><language><json:string>eng</json:string></language><abstract>The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</abstract><qualityIndicators><score>3.353</score><pdfVersion>1.4</pdfVersion><pdfPageSize>504 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>737</abstractCharCount><pdfWordCount>1821</pdfWordCount><pdfCharCount>11954</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>86</abstractWordCount></qualityIndicators><title>Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson 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type="first">S.</forename><surname>Jegou</surname></persName><affiliation>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</affiliation></author><author><persName><forename type="first">X.</forename><surname>Bertagna</surname></persName><affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</affiliation></author><author><persName><forename type="first">F.</forename><surname>Javoy-Agid</surname></persName><affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</affiliation></author><author><persName><forename type="first">D.</forename><surname>Seurin</surname></persName><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation></author><author><persName><forename type="first">M.F.</forename><surname>Proeschel</surname></persName><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation></author><author><persName><forename type="first">F.</forename><surname>Girard</surname></persName><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation></author><author><persName><forename type="first">Y.</forename><surname>Agid</surname></persName><affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</affiliation></author><author><persName><forename type="first">H.</forename><surname>Vaudry</surname></persName><affiliation>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</affiliation></author><author><persName><forename type="first">J.P.</forename><surname>Luton</surname></persName><affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</affiliation></author></analytic><monogr><title level="j">Neuroscience Letters</title><title level="j" type="abbrev">NSL</title><idno type="pISSN">0304-3940</idno><idno type="PII">S0304-3940(09)X9002-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984"></date><biblScope unit="volume">54</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="146">146</biblScope></imprint></monogr><idno type="istex">E38C574F3DB3EAC392E36B0802A6E0FA2DA25472</idno><idno type="DOI">10.1016/S0304-3940(85)80069-0</idno><idno type="PII">S0304-3940(85)80069-0</idno><idno type="ArticleID">80069</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>hypothalamus</term></item><item><term>Parkinson</term></item><item><term>pro-opiomelanocortin</term></item><item><term>radioimmunoassay</term></item><item><term>gel filtration</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1984-11-20">Registration</change><change when="1984-11-12">Modified</change><change when="1984">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.1.0//EN//XML" URI="art510.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.1" xml:lang="en" docsubtype="fla"><item-info><jid>NSL</jid><aid>80069</aid><ce:pii>S0304-3940(85)80069-0</ce:pii><ce:doi>10.1016/S0304-3940(85)80069-0</ce:doi><ce:copyright type="unknown" year="1985">Elsevier Scientific Publishers Ireland Ltd.</ce:copyright></item-info><head><ce:title>Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients</ce:title><ce:author-group><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Pique</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Jegou</ce:surname><ce:cross-ref refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>X.</ce:given-name><ce:surname>Bertagna</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Javoy-Agid</ce:surname><ce:cross-ref refid="aff3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.</ce:given-name><ce:surname>Seurin</ce:surname><ce:cross-ref refid="aff4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.F.</ce:given-name><ce:surname>Proeschel</ce:surname><ce:cross-ref refid="aff4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Girard</ce:surname><ce:cross-ref refid="aff4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Agid</ce:surname><ce:cross-ref refid="aff3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Vaudry</ce:surname><ce:cross-ref refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.P.</ce:given-name><ce:surname>Luton</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>3</ce:label><ce:textfn>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</ce:textfn></ce:affiliation><ce:affiliation id="aff4"><ce:label>4</ce:label><ce:textfn>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="26" month="3" year="1984"></ce:date-received><ce:date-revised day="12" month="11" year="1984"></ce:date-revised><ce:date-accepted day="20" month="11" year="1984"></ce:date-accepted><ce:abstract id="ab1"><ce:abstract-sec><ce:simple-para>The concentrations of γ<ce:inf>3</ce:inf>-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and <ce:italic>β</ce:italic>-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ<ce:inf>3</ce:inf>-melanotropin, <ce:italic>β</ce:italic>-endorphin and a lipotropin<ce:inf>37–58</ce:inf>-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Key words</ce:section-title><ce:keyword><ce:text>hypothalamus</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson</ce:text></ce:keyword><ce:keyword><ce:text>pro-opiomelanocortin</ce:text></ce:keyword><ce:keyword><ce:text>radioimmunoassay</ce:text></ce:keyword><ce:keyword><ce:text>gel filtration</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>X.Y.</ce:given-name><ce:surname>Bertagna</ce:surname></sb:author><sb:author><ce:given-name>W.E.</ce:given-name><ce:surname>Nicholson</ce:surname></sb:author><sb:author><ce:given-name>K.</ce:given-name><ce:surname>Tanaka</ce:surname></sb:author><sb:author><ce:given-name>G.D.</ce:given-name><ce:surname>Sorenson</ce:surname></sb:author><sb:author><ce:given-name>O.S.</ce:given-name><ce:surname>Pettengill</ce:surname></sb:author><sb:author><ce:given-name>C.D.</ce:given-name><ce:surname>Mount</ce:surname></sb:author><sb:author><ce:given-name>D.N.</ce:given-name><ce:surname>Orth</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Corticotropin, lipotropin and <ce:italic>β</ce:italic>-endorphin production by a human non-pituitary tumor in culture: evidence of a common precursor</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Proc. 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pituitary</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroendocrinology</sb:maintitle></sb:title><sb:volume-nr>30</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>113</sb:first-page><sb:last-page>121</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pique</namePart><affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Jegou</namePart><affiliation>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Bertagna</namePart><affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Javoy-Agid</namePart><affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Seurin</namePart><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.F.</namePart><namePart type="family">Proeschel</namePart><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Girard</namePart><affiliation>Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, F-75012 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Agid</namePart><affiliation>Laboratoire de Médecine Expérimentale, Chu Pltie-Salpetriere, Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Vaudry</namePart><affiliation>Groupe d'Endocrinologie Moléculaire, Faculté des Sciences, Rouen (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.P.</namePart><namePart type="family">Luton</namePart><affiliation>Laboratoire de la Clinique des Maladies Endocriniennes, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, F-75014 Paris (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1984</dateIssued><dateValid encoding="w3cdtf">1984-11-20</dateValid><dateModified encoding="w3cdtf">1984-11-12</dateModified><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</abstract><subject lang="en"><genre>Key words</genre><topic>hypothalamus</topic><topic>Parkinson</topic><topic>pro-opiomelanocortin</topic><topic>radioimmunoassay</topic><topic>gel filtration</topic></subject><relatedItem type="host"><titleInfo><title>Neuroscience Letters</title></titleInfo><titleInfo type="abbreviated"><title>NSL</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19850315</dateIssued></originInfo><identifier type="ISSN">0304-3940</identifier><identifier type="PII">S0304-3940(09)X9002-6</identifier><part><detail type="volume"><number>54</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue pages"><start>111</start><end>378</end></extent><extent unit="pages"><start>141</start><end>146</end></extent></part></relatedItem><identifier type="istex">E38C574F3DB3EAC392E36B0802A6E0FA2DA25472</identifier><identifier type="DOI">10.1016/S0304-3940(85)80069-0</identifier><identifier type="PII">S0304-3940(85)80069-0</identifier><identifier type="ArticleID">80069</identifier><accessCondition type="use and reproduction" contentType="">© 1985Elsevier Scientific Publishers Ireland Ltd.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Scientific Publishers Ireland Ltd., ©1985</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/E38C574F3DB3EAC392E36B0802A6E0FA2DA25472/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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